Plague

Every Plague relic that inflicts statuses keeps the same proportions: one part Poison, two parts Frost, three parts Burn. Plague Bauble opens combat with 3, 6 and 9, Plague Generator with 5, 10 and 15, and Plague Transmission Engine applies 10, 20 and 30 at the start and every 10 seconds. Plague Ascendancy asks for 25, 50 and 75 on one enemy, then applies those amounts to every enemy at the start of each combat. Duelist's Rhythm Prism follows the ratio too, randomly inflicting 2 Poison, 4 Frost or 6 Burn on each Duelist auto attack.

This is the one status family that reads both Rush and Stall. Plague Amplifier and Plague Accelerator work for Rush (12), giving an enemy 1 or 2 more whenever it would gain a Debuff, while Plague Harvester waits for Stall (15) before granting heroes 1 Defense and 1 Magic per 25 Debuffs on all enemies. Its quests pay only in Shards, Plague Collector 15 after 250 Debuffs and Plague Conduit 30 after 750, unlike the other status Conduits.

Payoffs that count types stop growing once Poison, Frost and Burn are all present: Plague Velocitizer gives 1 Attack Speed and 2 Attack per type every 4 seconds, Plague Amulet 4 Magic per type on cast, and Duelist's Outbreak Banner 20 bonus damage per type on each Duelist auto attack. Payoffs that count stacks have no such ceiling. Plague Harvester is one, and Mystic's Protection Banner shields the nearest hero for the total stack count on each Mystic cast. Pollen's The Fae's Kiss raises all Debuffs on enemies by 33% plus 33% per rank after Stall (30), which only the stack counters register.

Debuff Duelists carries Plague Velocitizer, Duelist's Outbreak Banner and nothing else. The Banner's 0.5.5 rewrite lifted the build, and the short relic list is what holds it at A. The heroes do the rest: Pimenta wears Frosted Gauntlets and Venomous Gauntlets, Sal's The Breezy gives Mages and Duelists Attack Speed and Magic whenever they inflict a Debuff, and Irini's Freezing Acceleration upgrade gives Duelists 2 Attack Speed against enemies with Frost. Debuff Mages takes Plague Amplifier instead.